

Choosing the right moisturizer can make all the difference for your clients. While both Oxygen Cream and Comfort Cream with Aloe Vera are powerful moisturizers, each one is designed for a different skin state. Once you understand exactly what sets them apart, you'll be able to build targeted protocols with confidence and help your clients see real, visible results.


GlyMed's Oxygen Cream is a light, soufflé-style Step 3 moisturizer that your clients will love. This product detoxifies skin cells, boosts microcirculation and oxygenates the skin barrier for deeper, lasting hydration. The result is a brighter, more luminous complexion that never feels heavy or greasy.
Oily, combination, normal, dry or acne-prone skin.
Oxygen Cream supports skin dulled by environmental stressors by increasing circulation, allowing cells to receive nutrients more effectively, resulting in a refreshed, more balanced complexion.
Apply morning and night to thoroughly cleansed skin—after you apply serums—on the face, neck and décolleté. Massage gently until absorbed, then follow with SPF 15+. If you’re targeting dryness or dehydration in particular, you can add another moisturizer before your SPF.
Use as a Step 3 moisturizer in acne, congestion, dullness, hyperpigmentation and photoaging protocols.


The Comfort Cream with Aloe Vera is a calming, anti-inflammatory daily moisturizer built around concentrated Aloe Vera. If your client's skin is feeling dry, irritated or sensitive after a professional treatment, this might be exactly what it needs. Our calming moisturizer soothes and supports the skin's natural recovery back to a balanced state.
Dry, dehydrated, sensitive or lipid-deficient skin, including clients presenting with eczema, flaking or post-service redness.
Comfort Cream with Aloe Vera replenishes the skin's lipid layer, which is the barrier that keeps moisture in and irritants out. It's acne-safe and gentle enough for use directly after exfoliation, waxing or extractions.
Apply morning and/or night to cleansed skin after serums, based on client need. Continue use until sensitivity resolves.
Ideal for clients following professional services, seasonal dryness, temporary sensitivity or ongoing barrier disruption.
Both of these products are crafted with pharmaceutical-grade formulations designed to deliver exceptional results. But to deliver those results, you need to know how best to use them.
Choose GlyMed's Oxygen Cream when…
Choose GlyMed's Comfort Cream when…


Whether you're building out a corrective program or focusing on barrier restoration, you'll find that each product has a clear and purposeful role to play in your protocols.
Absolutely, and in many cases, using both products together is the most beneficial! A client working through a corrective protocol might reach for GlyMed's Oxygen Cream in the morning to brighten and oxygenate, then wind down with the Comfort Cream with Aloe Vera at night to keep the skin calm and supported as it adjusts to actives. You could also mix the two products and apply them together.
This approach is especially useful during transition phases, when active concerns and mild sensitivity present simultaneously.
Oxygen Cream is designed for stable or corrective use and isn’t an active product, so it can be safely used for immediate post-peel recovery. However, after a peel, the skin barrier is more vulnerable and needs calming support. While Oxygen Cream can help kickstart the recovery process, Comfort Cream with Aloe Vera is better for barrier support until the barrier has stabilized before reintroducing actives.
No, Comfort Cream with Aloe Vera is acne-safe and appropriate for most skin types. Its anti-inflammatory properties make it a sound option for acne-prone clients also experiencing sensitivity or barrier disruption alongside breakouts.
Yes. Oxygen Cream supports corrective protocols targeting acne, hyperpigmentation and dullness. Comfort Cream with Aloe Vera fits post-treatment phases where calming and barrier integrity take priority. Both can be sequenced into a protocol based on your client's progress.
Both are excellent options for mature skin! Oxygen Cream supports brightening via Tetrahexyldecyl Ascorbate and promotes cellular oxygenation and collagen support. If the client also presents with dryness or sensitivity, Comfort Cream with Aloe Vera can be incorporated at night for added nourishment.
Comfort Cream with Aloe Vera is typically the superior choice for dehydrated skin, since its Aloe Vera base actively soothes and replenishes moisture-depleted skin. For clients experiencing dehydration alongside congestion or dullness, GlyMed's Oxygen Cream can also provide meaningful barrier hydration support.
Confident product recommendations come from knowing the formulations, and that knowledge can expand the more you engage with the GlyMed+ system. As a GlyMed+ Pro, you can gain access to the full product range, exclusive protocols and ongoing education designed to sharpen your clinical decision-making.
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